QSAR: a abordagem de Hansch

QSAR : Hansch Analysis and Related Approaches

In tribute to Corwin Hansch, father of QSAR

In this issue of Journal of Computer-Aided Molecular Design we pay tribute to Corwin Hansch, who died on May 8 at the age of 91. Professor Hansch (Corwin to almost everyone, at his insistence) was a giant in our field, the ‘father’ of QSAR, and the vanguard of rational drug design. Thanks to his long-time colleague and coworker, Cynthia Selassie, also of Pomona College, we are, with sadness, pu...

A Abordagem de Engenharia de Requisitos em Software Legado

The article proposal to approach a non functional and functional requirements information recovery model of legacy software, using quality measures applied to software use context. Early, it evaluates effectiveness, productivity, safety and satisfaction of user in the use software. In sequence, it use reference guide for analysis of delivery products in the project phase, lets quality metrics a...

From Hansch-Fujita Analysis to AFMoC: A Road to Structure-Based QSAR.

Since the pioneering effort of Hansch and Fujita, quantitative structure-activity relationships (QSAR) have proved valuable in optimizing lead structures. Enriching classical 3D-QSAR analysis, which exploits the three-dimensional structure of ligands, with structural information of the target has helped to improve the interpretability of the derived models and to increase their predictive power...

Uma Abordagem Metodológica para a Elaboração de Planos de Estimação em Projectos de Desenvolvimento de Software

O presente artigo apresenta uma proposta para a elabora8o de um piano de estimaq5o de custos/esforo/prazos na ea de desenvolvimento de Software (SW). 0 8mbito de aplicaAo deste m6todo de estimao est:i inserido na lase de planeamento do ciclo .da gesto de projectos, jd que fornece uma aproximao ao esforVo e caste requeridos para produzir os entreg6veis definidos na relaVo fomecedor-cliente consi...